The π-helix translates structure into function

Antisense Translates into Sense

T he paradigm that DNA is the central bank of genetic information within the cell, and that portions of the DNA are copied via transcription to RNA, which is subsequently decoded to synthesize protein in a cell, is basically true throughout cellular evolution. However, it is also true that although this is a general blueprint for regulating how genes are expressed, evolution, with its varied se...

Smoothened translates Hedgehog levels into distinct responses.

In the Drosophila wing, Hedgehog is made by cells of the posterior compartment and acts as a morphogen to pattern cells of the anterior compartment. High Hedgehog levels instruct L3/4 intervein fate, whereas lower levels instruct L3 vein fate. Transcriptional responses to Hedgehog are mediated by the balance between repressor and activator forms of Cubitus interruptus, CiR and CiA. Hedgehog reg...

Approximation by Translates of a Radial Function

Interpolation by Translates of a Basis Function

Interpolation using radial basis functions has become an established and useful technique in multi-dimensional data tting. It is a special case of interpolation by translates of a basis function. All the methods used in practice have a strong connection with a variational principle. In this paper we provide a straightforward approach to the variational principle, and make some useful practical ...

A light-driven three-dimensional plasmonic nanosystem that translates molecular motion into reversible chiroptical function

Nature has developed striking light-powered proteins such as bacteriorhodopsin, which can convert light energy into conformational changes for biological functions. Such natural machines are a great source of inspiration for creation of their synthetic analogues. However, synthetic molecular machines typically operate at the nanometre scale or below. Translating controlled operation of individu...